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| Registros recuperados: 273 | |
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| Michael E. Baker. |
| In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from animals that are at key sites in vertebrate evolution. Although the estrogen receptor [ER] appears to be the ancestral vertebrate steroid receptor and estradiol [E2] is the physiological ligand for vertebrate ERs, the identity of the ancestral ligand(s) for the ER remains unknown. Here, using an analysis of crystal structures of human ER[alpha] with E2 and other chemicals and 3D models of human ER[alpha] with 27-hydroxycholesterol and 5-androsten-3[beta],17[beta]-diol, we propose that one or more [DELTA]5... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Developmental Biology; Ecology; Genetics & Genomics; Pharmacology; Bioinformatics; Earth & Environment; Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5777/version/1 |
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| Ivan Spasojevic. |
| To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated. Because there are no such laws yet, there is usually a long path for physiological findings obtained by reductionist approaches to be translated into medical practice. The concept and accompanying equations of homeostasis presented here are aimed to develop biological laws and to bridge this gap between physiology and medicine. The concept of homeostasis takes into account energy input and output, enlisting all relevant contributors. In homeostasis, input should equal the output. What I suggest here is that if the system is out of homeostasis, the... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Molecular Cell Biology; Neuroscience; Pharmacology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6741/version/1 |
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| Ivan Spasojevic. |
| To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated. Because there are no such laws yet, there is usually a long path for physiological findings obtained by reductionist approaches to be translated into medical practice. The concept and accompanying equations of homeostasis presented here are aimed to develop biological laws and to bridge this gap between physiology and medicine. The concept of homeostasis takes into account energy input and output, enlisting all relevant contributors. In homeostasis, changes in the input should equal changes in the output within any specific period of time. What I... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Molecular Cell Biology; Neuroscience; Pharmacology; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6741/version/2 |
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| Suaib Luqman. |
| Vetiveria zizanioides L. Nash synonymously known as Chrysopogon zizanioides L. Roberty (Family: Poaceae/Graminae), widely cultivated in the tropical regions of the world, is a miraculous grass native to India first developed for soil and water conservation by the World Bank during mid 1980s. Popularly known as ‘KHUS’, it is the major source of the well-known oil of vetiver, which is used in medicine, cosmetics and in perfumery making agarbattis, soaps, soft drinks, pan masala. Being a major constituent of ‘Rasayana’ in Ayurveda, different parts of the vetiver plant have traditionally been used by the Indian tribes for treating various ailments, diseases and disorders including boils, burns, epilepsy, fever,... |
| Tipo: Poster |
Palavras-chave: Cancer; Microbiology; Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6904/version/1 |
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| Joanna L. Sharman; Valerie A. Hale; Rebecca Hills; Edward M. Rosser; Martin Jones; Stuart D. Greenhill; Anthony J. Harmar; NC - IUPHAR. |
| The International Union of Basic and Clinical Pharmacology database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 non-sensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of about a third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. Individual gene pages provide a comprehensive description of the genes and their functions, with information on protein structure, ligands, expression patterns, signaling mechanisms, functional assays and biologically... |
| Tipo: Poster |
Palavras-chave: Pharmacology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3230/version/1 |
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| Harika Meduru; Dibyabhaba Pradhan; Manne Munikumar; Amineni Umamaheswari. |
| Human dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. Upon phosphorylation, MAP2K4 has been shown to activate MAPK8, MAPK9 and MAPK14/p38 but not MAPK1/ERK2 or MAPK3/ERK1. Over expression of MAP2K4 causes carcinogenic effects, such as ovarian cancer, colorectal cancer, prostate cancer and pancreatic cancer. Our present study was carried out to design a potent drug molecule against MAP2K4 to control over expression. As there is no experimentally determined structure for MAP2K4, the homology modeling technique of Modeller9v7 was implemented to generate a MAP2K4 3D model based on the co-crystal structure of MAP2K6 (PDB ID: 3FME) with... |
| Tipo: Poster |
Palavras-chave: Cancer; Pharmacology; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5457/version/1 |
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| Rodrick Wallace. |
| For a broad spectrum of low level cognitive regulatory and other biological phenomena, isolation from signal crosstalk between them requires more metabolic free energy than permitting correlation. This allows an evolutionary exaptation leading to dynamic global broadcasts of interacting physiological processes at multiple scales. The argument is similar to the well-studied exaptation of noise to trigger stochastic resonance amplification in physiological subsystems. Not only is the living state characterized by cognition at every scale and level of organization, but by multiple, shifting, tunable, cooperative larger scale broadcasts that link selected subsets of functional modules to address problems. This multilevel dynamical viewpoint has implications... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Developmental Biology; Immunology; Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6973/version/1 |
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| Bidhan C. Bandyopadhyay; Lina Chakrabarti; Mrinal K. Poddar. |
| Amounts of dietary protein as well as the duration of its supplementation are critical
factors that correlate with the hypothalamic GABAergic activity and immune function
during aging. Here we evaluate the effect of low (5%) and high (40%) protein diet on the
functional state of hypothalamic GABA receptor in the aging brain in albino rats. Longterm
(LT; for 30 consecutive days) supplementation of low protein diet (LDP) retarded
the age-associated (3 to 18 months) (a) loss of both low and high affinity hypothalamic
GABA receptor sensitivity and (b) increase of high affinity GABA receptor density.
Short-term (ST; for 7 consecutive days)... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2284/version/1 |
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| Rodrick Wallace. |
| Western medicine's paradigmatic search for 'magic bullet' interventions is facing increasing difficulty: Between 1950 and 2010 the inflation-adjusted cost per USFDA-approved drug has increased exponentially in time, a draconian inverse of the famous Moore's Law of computing. A sequence of empirically-oriented statistical models suggests that carefully designed synergistic multifactorial and multiscale strategies might evade this relationship. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6780/version/1 |
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| Daniel Belluscio; Nestor Lago; Ezequiel Klimovsky; Maria Berdeal; Andrea Federico. |
| Objectives: To elucidate the relationship of hCG administration to glycemia, Non Esterified Fatty Acids (NEFA), leptin and adiponectin levels on experimental animals previously submitted to a cafeteria diet, and then to a Low Calorie Diet (LCD). Design: Forty-one rats were selected (21 females, 20 males) and divided into seven (0-6) groups. Animals from groups 1 to 6 were fed a "cafeteria diet" with a mean energy content of 10% protein, 30% carbohydrate and 60% fat. Animals from group 0 were fed the standard laboratory diet. After the fattening period, animals from groups 1 to 6 were submitted to a restricted diet consisting of one-third the average daily intake for rats. hCG was administered for five weeks according to a specific... |
| Tipo: Manuscript |
Palavras-chave: Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5781/version/1 |
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| Melissa A. Fowler; Andrew L. Varnell; Donald C. Cooper. |
| Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/- mice exhibit no difference in the locomotor response to low to moderate doses of cocaine (10 or 20 mg/kg). A high dose of cocaine (40 mg/kg) resulted in a blunted rather than absent locomotor response. We tested mGluR5 -/- and +/+ mice for conditioned place-preference to cocaine and found no group differences at a conditioning dose of 10 mg/kg, suggesting normal conditioned rewarding properties of cocaine. These... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6180/version/1 |
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| Melissa A. Fowler; Andrew L. Varnell; Donald C. Cooper. |
| Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/- mice exhibit no difference in the locomotor response to low to moderate doses of cocaine (10 or 20 mg/kg). A high dose of cocaine (40 mg/kg) resulted in a blunted rather than absent locomotor response. We tested mGluR5 -/- and +/+ mice for conditioned place-preference to cocaine and found no group differences at a conditioning dose of 10 mg/kg, suggesting normal conditioned rewarding properties of cocaine. These... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6180/version/2 |
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| Rahul Verma; Amit Misra. |
| In spite of extensive research in tuberculosis (TB), it is still one of the major infectious diseases and cause of high mortality worldwide. To enhance efficacy with lower dosing, newer drug delivery systems has been developed which provide targeted drug delivery and controlled release at the primary site of infection, i.e., the lung macrophage. Our lab has previously reported poly(D, L-lactic acid) (PLA) microparticles containing rifabutin (RFB) and isoniazid (INH) for pulmonary delivery and explored various facets of treatment with microparticle DPI. We have utilized this dry powder aerosol drug delivery system to deposit drugs directly at the site of infection in lungs and have been investigating such DPI as a novel approach to increase therapeutic... |
| Tipo: Poster |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7061/version/1 |
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| Registros recuperados: 273 | |
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